Negative chronotropic and antiarrhythmic properties of atropine and other tropane analogues on isolated cat heart preparations.

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Negative chronotropic and antiarrhythmic properties of atropine and other tropane analogues on isolated cat heart preparations.

This study was undertaken to characterize pharmacologically the negative chronotropic and antiarrhythmic action of atropine and other tropane analogues. Insight into the site of action of these drugs was obtained by comparing the effects on isolated heart preparations. Dose-response curves were constructed for the negative chronotropic action on the cat Langendorff preparation and refractory pe...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1978

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.42.4.467